Journal article
Recent Toolboxes for Chemoselective Dual Modifications of Proteins
Y Zhao, T Zhang, Y Zhu, J Yin, R Omer, X Hemu, W Li, X Bi
Chemistry A European Journal | WILEY-V C H VERLAG GMBH | Published : 2024
Abstract
Site-selective chemical modifications of proteins have emerged as a potent technology in chemical biology, materials science, and medicine, facilitating precise manipulation of proteins with tailored functionalities for basic biology research and developing innovative therapeutics. Compared to traditional recombinant expression methods, one of the prominent advantages of chemical protein modification lies in its capacity to decorate proteins with a wide range of functional moieties, including non-genetically encoded ones, enabling the generation of novel protein conjugates with enhanced or previously unexplored properties. Among these, approaches for dual or multiple modifications of protein..
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Grants
Awarded by China Pharmaceutical University
Funding Acknowledgements
This work was supported by the grant from Zhejiang Provincial Natural Science Foundation of China under Grant No. LY24B020008 and Zhejiang University of Technology High-Level Talents Startup Funds (2021414800229, X. B. Bi). X. Hemu is the recipient of National Natural Science Foundation of China (No. 32371324), National Key Research and Development Program of China (No. 2023YFA0916000) and the High-level Talent Startup Fund by China Pharmaceutical University. W.L. is the recipient of NHMRC Investigator Grant EL1 (APP2018256) and Ramaciotti Health Investment Grant. Open Access publishing facilitated by La Trobe University, as part of the Wiley - La Trobe University agreement via the Council of Australian University Librarians.